Endocrine Abstracts

Introduction: Hyperuricemia is increasingly being considered a potential pathogenic factor for T2DM, metabolic syndrome, and several adverse consequences of vascular disease. It has been suggested that xanthine oxidase may underlie the urine acid-T2DM association. The study aimed to determine the associations between clinical parameters, glucose homeostasis, and SXO activity in patients with T2DM.Methods: 125 patients with T2DM, age (58.9±9.4) years...

Aim: The aim is to study the clinical and hormonal peculiarities of PROL (prolactinoma), manifesting in people under the age of 18 and monitoring the effectiveness of suppressive CAB (Cabergoline, Dostinex) therapy during 12 months period.Materials and methods: The total study included 11 patients with PROL, manifesting in childhood. There were also examined 54 healthy volunteers (25 males and 29 females) aged 15–19 to determine the range of normal ...

Introduction: Cardiovascular complications are the most relevant cause of mortality in patients with acromegaly.Aims: To evaluate the association of diurnal melatonin profile with arterial hypertension in acromegalic patients.Subjects and methods: Thirty seven patients (15 men and 22 women; aged 18–75 years) with acromegaly were under investigation. Blood samples for GH and, IGF1 were taken in fasting state. 6-Sulfatoxymelaton...

Introduction: Cardiovascular complications are the most relevant cause of mortality in patients with acromegaly.Aims: To evaluate the effects of chronic excess of GH, IGF1 and PRL on blood pressure, heart rate and pulse in patients with active acromegaly.Subjects and methods: Sixty-three patients (22 men and 41 women; aged 18–76 years) with macroadenoma of hypophysis (45 – somatotropinoma, 19 – somatomammotropinoma) ...

IntroductionThe practice of screening for many chronic diseases, particularly endocrine pathology, is taking place all over the world. The relevance of screening increases significantly when we are talking about diseases with a torpid manifestation and absence of certain clinical symptoms in the debut. Such diseases include pathological conditions caused by pituitary hormone hypersecretion, in particular, acromegaly.The aim<p c...

Introduction: Publications suggesting that thyroid nodules might be associated with insulin resistance (IR) and metabolic syndrome are quite interesting. The aim of the work is to analyze the association between anthropometric indicators IR and insulin-like growth factor-1 (IGF-1) in patients with nodular goiter. Methods Examined 73 patients with euthyroid single-node (n=34) and multinodular goiter (n=39), age (51.0&pm;10.6) years; determinin...